Chem. Pharm. Bull. 53(10) 1338—1341 (2005)
نویسندگان
چکیده
from the genus Ligularia (Compositae) plants we have studied the roots of Ligularia tongolensis (FRANCH) HANDMAZZ collected in mountainous areas (altitude: 3600 m) in southwestern China. Ligularia tongolensis is used as a traditional folk medicine in China and its roots can reduce phlegm, relieve coughing and cure pulmonary tuberculosis, urinary track blockages, common cold, and pharyngitis. However, the chemical constituents of this plant have not been reported up until now. In this paper, we report the isolation and structural elucidation of four new compounds (1, 2, 7, 8) and nine known compounds 3, 4, 5, 6, 9, 10, 11, 12 and 13 from its roots. In addition, the cytotoxic activity in vitro of compounds 1, 2, 3, 7 and 8 were tested against human hepatoma (SMMC-7721), human embryo liver (L-02) and human leukemia (HL-60) cell lines with 10hydroxycamptothecine as a standard.
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